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Company

i-SEP is a French Medtech, founded in 2015 in Nantes, specialized in intraoperative autotransfusion and Patient Blood Management. At i-SEP, we have developed and patented an innovative technology for the recovery and separation of blood components.

Our ambition is to become the first laboratory to market intraoperative cell salvage technology (IOCS) capable of recovering both red blood cells and platelets during hemorrhagic surgery, using equipment that is ergonomic and intuitive.

We work closely with teams of reference anesthetists and resuscitation specialists with the aim of improving patient benefits, simplifying the work of physicians and helping to reduce healthcare costs.

Our innovation brings significant added value compared to currently available solutions, particularly in terms of blood quality.

History

Before-founding
  • First proof of concept
  • First family of patent filed
  • Business plan drafted
Oct 2015

Founded 

  • €860,000 seed capital from the Go Capital Amorcage venture capital fund
2016
  • Market study
  • Team formed
  • Board of experts set up
  • Separation process developed
2017
  • First working prototype
  • In-vitro evaluation (French National Blood Bank for Nantes – Pays de la Loire)
  • In-vivo evaluation (Oniris Veterinary School)
  • Fundraising (round 1) of €1.23 million from Go Capital Amorçage and Business Angels
  • Regulatory strategy (EU and USA) and quality approach
2018
  • Move to Nantes BioOuest business incubator
  • Installation of a clean room and clean laboratories
  • Development and evaluation of the 2nd generation functional prototype
  • Fundraising (round 2) of €500,000 from Go Capital Amorçage
  • Bpifrance funding of €2.339 million and ERDF funding of €519,000.
  • Bpifrance Excellence label
2019
  • Development and evaluation of the 3rd generation prototype (clinical version)
  • Regulatory Validations
  • €2.134 million from Go Capital Amorçage and private investors
  • Winner in the “Revolution” category at the 2019 Run Innov Awards (Pays de La Loire)
  • Participation and communication in first congresses : SFAR, EUROPHARMAT
2020
  • ISO 13485 certification for the complete activity
  • Manufacturing of clinical machines
  • Authorization from ANSM and FAMHP, Medical Drug Regulators of France and Belgium respectively to launch clinical trial for CE pre-marking

i-SEP was co-founded by three partners: Dr Francis Gadrat, an anesthesiologist, Bertrand Chastenet, a former company director, consultant in the pharmaceutical industry and advisor to the National Committee of French Foreign Trade, and Sylvain Picot, a Medtech entrepreneur and founder of Biom’Up. i-SEP is financed by the Go Capital venture capital fund and a number of private investors. i-SEP is supported by Atlanpole and is a member of the Atlanpole Biotherapies competitiveness cluster.

Dr. Francis GADRAT

Dr. Francis GADRAT, inventor and co-founder, i-SEP Chief Medical Officer

Francis practiced for more than 40 years as an anesthesiologist at the Bordeaux University Hospital. He has also taken part in humanitarian missions. Very involved in the field of Patient Blood Management, Francis wants to reduce the side effects induced by surgical bleeding and to improve the post-operative recovery of patients. His clinical research work has led to the creation of an innovative intraoperative cell salvage technology (IOCS) capable of recovering both red blood cells and platelets. As a key contact for physicians and opinion leaders in Patient Blood Management, Francis makes sure that the device can simplify the work of physicians.

Bertrand CHASTENET

Bertrand CHASTENET, expert in the pharmaceutical sector, co-founder and Member of the i-SEP Strategic Committee

Bertrand brings i-SEP a strong management experience in the pharmaceutical sector. As Managing Director of FURT Laboratories for 20 years, Bertrand has collaborated with the Institut Curie on cancer research programs and has also been a consultant for the international development of several pharmaceutical companies. He currently acts as Advisor to the National Committee of French Foreign Trade in several educational programs. Bertrand assists i-SEP with the elaboration of its development strategy.

Sylvain PICOT

Sylvain PICOT, Medtech entrepreneur, co-founder, Chairman and CEO of i-SEP

A Biosciences Engineer from INSA Lyon and an experienced entrepreneur, Sylvain completed his training at the Lyon School of Management before setting up Biom’up which he managed for 10 years. Sylvain oversaw the development of new implantable medical devices from research to market in Europe and the USA. Sylvain joined Francis and Bertrand to found i-SEP to manage the development, approval and marketing of the innovative intraoperative cell salvage technology. In particular, Sylvain brings i-SEP his experience in launching an innovative activity in the field of surgical medical devices.

The team now counts about fifteen people managed by 4 experienced managers

Patricia FOREST-VILLEGAS
CSO, Regulatory Affairs & Quality Manager

A biochemical engineer from the INSA Engineering University of Lyon, Patricia completed her training with a Ph.D in biological and medical engineering. before founding and managing Biom’Up with Sylvain Picot for 10 years. She has developed extensive experience in the registration of medical devices in Europe and the United States and in the implementation of the company’s Quality System, which is ISO 13485 certified.

Stéphane CHOLLET
Technical Director

A Health & Safety Engineer from the University of Compiègne, Stéphane has more than 20 years of experience in the health sector, including a dozen years spent in development, industrialization, manufacturing and management functions in the field of transfusion. Stéphane joined i-SEP to oversee our technical and analytical development and industrialization phases. His solid skills in the development of blood consumables gleaned during his time with Macopharma and his experience as Quality Director give him a broad understanding of the subject.

 

 

Stéphanie PERRIN
Clinical Director

A biochemical engineer from INSA Lyon, Stéphanie completed her training with a Ph.D in biological and medical engineering. She then accumulated over 15 years of experience in clinical research on a range of medical devices, firstly in a hospital environment, and then with a CRO. This enabled her to develop solid skills in setting up and piloting clinical studies, but also in regulatory, project and team management aspects and in setting up hospital partnerships.
On joining i-SEP, Stéphanie was tasked with leading the clinical development, supporting regulatory compliance, completing the scientific and medical development, and launching the technology in partnership with hospital teams.

Guillaume LAURENT
Commercial & Marketing Director

A graduate of IDRAC Business School and holder of a Masters in Management of Technology & Innovation from GEM (Grenoble École de Management). Guillaume brings more than 10 years of experience in France and internationally in marketing, launching innovative medical devices and a solid knowledge of the healthcare market and opinion leaders.
Guillaume joined i-SEP in 2019 to promote our development, structure our marketing strategy and oversee the market release of our innovative intraoperative cell salvage technology in partnership with selected hospitals.

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Commitment and Quality

Since our creation, we have embraced a quality-focused approach to ensure the safety and performance of our devices. The ISO 13485: 2016 certification of its entire quality system in January 2020 was a fundamental step for the laboratory and the certification of its technologies and demonstrates i-SEP's expertise and complete control of all its activities.

Our teams are fully committed to ongoing improvement and we work in full compliance with the regulations in force.

Our overriding goal is to develop innovative medical devices to improve patient care and generalize the use of its devices by offering safe, effective and intuitive solutions for anesthetists and patients.

CE marking in preparation with BSI
European clinical trial planned for Q1 2021

Partners and investors

Investors

PRIVATE Investors

Since 2017, i-SEP has opened much of its capital to private investors, including several entrepreneurs from the healthcare sector who bring specific expertise in the clinical field or medical biology.

The fund raising round carried out in June 2019 with the support of GWENNEG consolidated our shareholder base with the arrival of new Business Angels and Family offices.

GO CAPITAL is a venture capital fund managing over €200 million in assets. The fund is mainly active in innovative, technology-intensive companies based in the West of France.

The GO CAPITAL Amorçage fund, which invested in the capital of i-SEP, was raised with the support of the Fonds National d’Amorçage, managed by Bpifrance Investissement as part of the PIA Investing-for-the-Future Program, the European Investment Fund, the Regions of Brittany, Pays de la Loire, Normandy and a selection of banking partners (Crédit Mutuel ARKEA, Caisses Régionales du Crédit Agricole and Caisse d’Epargne de Normandie).

GO CAPITAL is recognized as one of the most active seed capital investors in France in the healthcare field.

Interested in investing?

Our mission is to improve patient benefit, simplify the work of physicians and help reduce healthcare costs.

By putting the patient at the heart of its priorities, i-SEP develops innovative medical devices, including an autotransfusion system capable of recovering both red blood cells and platelets during hemorrhagic surgery, using equipment that is ergonomic and intuitive.

If you are interested in investing in a Medtech with strong ambitions and unique expertise, feel free to contact us.